Abstract

The aim of this review is to provide an overview of proteomic studies in animal models of diabetes and to give some insight into the different methods available today in the rapidly developing field of proteomics. A summary of 31 papers published between 1997 and 2007 is presented. For instance, proteomics has been used to study the development of both type 1 and type 2 diabetes, diabetic complications in tissues like heart, kidney and retina and changes after treatment with anti-diabetic drugs like peroxisome proliferator-activated receptors agonists. Together, these studies give a good overview of a number of experimental approaches. Proteomics holds the promise of providing major contributions to the field of diabetes research. However, to achieve this, a number of issues need to be resolved. Appropriate data representation to facilitate data comparison, exchange, and verification is required, as well as improved statistical assessment of proteomic experiments. In addition, it is important to follow up the results with functional studies to be able to make biologically relevant conclusions. The potential of proteomics to dissect complex human disorders is now beginning to be realized. In the future, this will result in new important information concerning diabetes.

Keywords

animal models of diabetes; diabetic complications; diabetic treatment; type 1/2 diabetes

Published in

PROTEOMICS - Clinical Applications
2008, Volume: 2, number: 5, pages: 654-669

UKÄ Subject classification

Cell and Molecular Biology


Publication identifier

DOI: https://doi.org/10.1002/prca.200780030

Permanent link to this page (URI)

https://res.slu.se/id/publ/38702