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Research article - Peer-reviewed, 2011

MAOA genotype, family relations and sexual abuse in relation to adolescent alcohol consumption.

Nilsson, Kent W.; Comasco, Erika; Åslund, Cecilia; Nordquist, Niklas; Leppert, Je, Oreland L

Abstract

The aim of the present study was to investigate MAOA gene-environment (G*E) interactions in relation to adolescent alcohol consumption. In the county of Västmanland, Sweden, all 17-18-year-old students were asked to complete an anonymous questionnaire and provide a saliva sample during class hours. A total of 2263 students completed the questionnaire (77.4%) and a saliva sample was provided by 2131 participants. Failed MAOA u-variable number of tandem repeats (VNTR) genotype analyses and internal non-responses left 851 boys and 735 girls (total n=1586) to be investigated. Alcohol use disorder identification test was used to measure hazardous alcohol consumption. MAOA u-VNTR was used to measure biological risk in interaction with poor family relations and experience of sexual abuse. The model was also adjusted for non-independent socioeconomic variables, separated parents, type of housing and parental unemployment. Results showed that the MAOA u-VNTR, in interaction with psychosocial risk factors, such as the quality of family relations and sexual abuse, was related to high alcohol consumption among adolescents. Girls, carrying the long MAOA u-VNTR variant showed a higher risk of being high alcohol consumers, whereas among boys, the short allele was related to higher alcohol consumption. The present study supports the hypothesis that there is a relation between MAOA u-VNTR and alcohol consumption and that this relation is modulated by environmental factors. Furthermore, the present study also supports the hypothesis that there is a sex difference in the G*E interaction.

Published in

Addiction Biology
2011, Volume: 16, number: 2, pages: 347-55

    UKÄ Subject classification

    Medical Genetics
    Substance Abuse
    Psychiatry

    Publication identifier

    DOI: https://doi.org/10.1111/j.1369-1600.2010.00238.x

    Permanent link to this page (URI)

    https://res.slu.se/id/publ/38708