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Research article2012Peer reviewedOpen access

Antiphagocytic Function of an IgG Glycosyl Hydrolase from Streptococcus equi subsp equi and Its Use as a Vaccine Component

Flock, Margareta; Frykberg, Lars; Sköld, Markus; Guss, Bengt; Flock, Jan-Ingmar

Abstract

Endo Se from Streptococcus equi subsp. equi is an enzyme hydrolyzing glycosyl groups on IgG, analogous to EndoS from Streptococcus pyogenes. We here show that the activity of EndoSe leads to an antiphagocytic function and may thus be a contributory factor to immune evasion of S. equi. Despite the damaging effect that EndoSe has on IgG, antibodies against EndoSe can neutralize its function. Antibodies against EndoSe restored the opsonic activity of specific opsonizing antibodies. Mice infected with either S. equi subsp. equi or subsp. zooepidemicus or S. pyogenes could be protected by vaccination with EndoSe. It is speculated that EndoSe could be a suitable vaccine candidate against streptococcal infections.

Published in

Infection and Immunity
2012, Volume: 80, number: 8, pages: 2914-2919
Publisher: AMER SOC MICROBIOLOGY

      SLU Authors

      • Sustainable Development Goals

      Ensure healthy lives and promote well-being for all at all ages

      UKÄ Subject classification

      Other Veterinary Science
      Genetics
      Microbiology

      Publication identifier

      DOI: https://doi.org/10.1128/IAI.06083-11

      Permanent link to this page (URI)

      https://res.slu.se/id/publ/41501