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Research article - Peer-reviewed, 2013

Intramuscular administration of sodium benzylpenicillin in horses as an alternative to procaine benzylpenicillin

Olsén, Lena; Bremer, Hanna; Olofsson, Karin; Bröjer, Johan; Bondesson, Ulf; Bergh, Anna; Nostell, Katarina; Broström, Hans; Bengtsson, Björn; Ingvast Larsson, Carina

Abstract

The aim was to supply information about the possibility of replacing the procaine salt with the sodium salt for benzylpenicillin IM treatment in horse in order to diminish the risk for procaine adverse effects. In a crossover study eight horses were given 15 mg/kg sodium benzylpenicillin (Na-pc) twice daily or procaine benzylpenicillin (control) once daily IM for four days. The half-life of Na-pc was 1.9 h, peak concentration was 14,600 ng/mL reached after about 23 min. Trough plasma concentration Was 281 ng/mL and protein binding 62.8%. The fT > MIC for Staphylococcus aureus was 63% and 100% for Streptococcus equi subsp. equi and Streptococcus zooepidemicus, indicating an adequate antimicrobial therapy. However, Na-pc cannot be recommended from a welfare point of view since the horses showed more pain related behaviour and more pain and swelling compared to the control treatment. (c) 2013 Elsevier Ltd. All rights reserved.

Published in

Research in Veterinary Science
2013, volume: 95, number: 1, pages: 212-218
Publisher: Elsevier

Authors' information

Olsén, Lena
Swedish University of Agricultural Sciences, Department of Biomedical Science and Veterinary Public Health
Bremer, Hanna
Swedish University of Agricultural Sciences, Department of Biomedical Science and Veterinary Public Health
Olofsson, Karin
Swedish University of Agricultural Sciences, Department of Biomedical Science and Veterinary Public Health
Bröjer, Johan
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Bondesson, Ulf
Bergh, Anna
Swedish University of Agricultural Sciences, Department of Anatomy, Physiology and Biochemistry (AFB)
Nostell, Katarina
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Broström, Hans
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Bengtsson, Björn
National Veterinary Institute (SVA)
Ingvast Larsson, Carina
Swedish University of Agricultural Sciences, Department of Biomedical Science and Veterinary Public Health

UKÄ Subject classification

Pathobiology

Publication Identifiers

DOI: https://doi.org/10.1016/j.rvsc.2013.01.019

URI (permanent link to this page)

https://res.slu.se/id/publ/42551