Abstract

The aim was to supply information about the possibility of replacing the procaine salt with the sodium salt for benzylpenicillin IM treatment in horse in order to diminish the risk for procaine adverse effects. In a crossover study eight horses were given 15 mg/kg sodium benzylpenicillin (Na-pc) twice daily or procaine benzylpenicillin (control) once daily IM for four days. The half-life of Na-pc was 1.9 h, peak concentration was 14,600 ng/mL reached after about 23 min. Trough plasma concentration Was 281 ng/mL and protein binding 62.8%. The fT > MIC for Staphylococcus aureus was 63% and 100% for Streptococcus equi subsp. equi and Streptococcus zooepidemicus, indicating an adequate antimicrobial therapy. However, Na-pc cannot be recommended from a welfare point of view since the horses showed more pain related behaviour and more pain and swelling compared to the control treatment. (c) 2013 Elsevier Ltd. All rights reserved.

Published in

Research in Veterinary Science
2013, Volume: 95, number: 1, pages: 212-218
Publisher: Elsevier

SLU Authors

• Olsén, Lena

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Olofsson, Karin

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Bröjer, Johan

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

• Bergh, Anna

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Nostell, Katarina

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

• Broström, Hans

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

• Ingvast Larsson, Carina

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Pathobiology


Publication identifier

DOI: https://doi.org/10.1016/j.rvsc.2013.01.019

Permanent link to this page (URI)

https://res.slu.se/id/publ/42551