Research article - Peer-reviewed, 2013
Intramuscular administration of sodium benzylpenicillin in horses as an alternative to procaine benzylpenicillin
Olsén, Lena; Bremer, Hanna; Olofsson, Karin; Bröjer, Johan; Bondesson, Ulf; Bergh, Anna; Nostell, Katarina; Broström, Hans; Bengtsson, Björn; Ingvast Larsson, CarinaAbstract
The aim was to supply information about the possibility of replacing the procaine salt with the sodium salt for benzylpenicillin IM treatment in horse in order to diminish the risk for procaine adverse effects. In a crossover study eight horses were given 15 mg/kg sodium benzylpenicillin (Na-pc) twice daily or procaine benzylpenicillin (control) once daily IM for four days. The half-life of Na-pc was 1.9 h, peak concentration was 14,600 ng/mL reached after about 23 min. Trough plasma concentration Was 281 ng/mL and protein binding 62.8%. The fT > MIC for Staphylococcus aureus was 63% and 100% for Streptococcus equi subsp. equi and Streptococcus zooepidemicus, indicating an adequate antimicrobial therapy. However, Na-pc cannot be recommended from a welfare point of view since the horses showed more pain related behaviour and more pain and swelling compared to the control treatment. (c) 2013 Elsevier Ltd. All rights reserved.Published in
Research in Veterinary Science2013, volume: 95, number: 1, pages: 212-218
Publisher: Elsevier
Authors' information
Swedish University of Agricultural Sciences, Department of Biomedical Science and Veterinary Public Health
Bremer, Hanna
Swedish University of Agricultural Sciences, Department of Biomedical Science and Veterinary Public Health
Olofsson, Karin
Swedish University of Agricultural Sciences, Department of Biomedical Science and Veterinary Public Health
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Bondesson, Ulf
Swedish University of Agricultural Sciences, Department of Anatomy, Physiology and Biochemistry (AFB)
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Broström, Hans
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Bengtsson, Björn
National Veterinary Institute (SVA)
Ingvast Larsson, Carina
Swedish University of Agricultural Sciences, Department of Biomedical Science and Veterinary Public Health
UKÄ Subject classification
Pathobiology
Publication Identifiers
DOI: https://doi.org/10.1016/j.rvsc.2013.01.019
URI (permanent link to this page)
https://res.slu.se/id/publ/42551