Moritz, Thomas
- Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences
ALS-patients with a SOD1 gene mutation appear as a distinct metabolic entity in the CSF, in particular in patients with the D90A mutation, the most frequently identified cause of ALS. The findings suggest that metabolomic profiling using GC-TOFMS and multivariate data analysis may be a future tool for diagnosing and monitoring disease progression, and may cast light on the disease mechanisms in ALS. (C) 2011 Elsevier Inc. All rights reserved.
Amyotrophic lateral sclerosis (ALS); Biomarker; Chemometrics; Cerebrospinal fluid (CSF); D90A SOD1; Metabolomics
Molecular Genetics and Metabolism
2012, volume: 105, number: 3, pages: 472-478
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
Neurosciences
https://res.slu.se/id/publ/42599