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Research article - Peer-reviewed, 2009

Sesquiterpenes of the Geosmin-Producing Cyanobacterium Calothrix PCC 7507 and their Toxicity to Invertebrates

Höckelmann, Claudia; Becher, Paul G; von Reuss, Stephan H.; Jüttner, Friedrich


The occurrence of sesquiterpenes was investigated with the geosmin-producing cyanobacterium Calothrix PCC 7507. The essential oil obtained by vacuum destillation was studied in more detail by GC-MS methods and superposition with authentic compounds. Geosmin was the dominating compound while the other sesquiterpenes were minor components. Sesquiterpenes that have not been described before in cyanobacteria were isodihydroagarofuran, eremophilone and 6,11-epoxyisodaucane. Closed-loop stripping analysis revealed that most of the sesquiterpenes were found in the biomass of Calothrix, while eremophilone was mainly observed in the medium of the axenic culture. Eremophilone showed acute toxicity (LC(50)) against Chironomus riparius (insecta) at 29 mu M and against Thamnocephalus platyurus (crustacea) at 22 mu M. The compound was not toxic for Plectus cirratus (nematoda). 6,11-Epoxyisodaucane and isodihydroagarofuran exhibited no toxicity to invertebrates when applied ill concentrations up to 100 mu M.


Sesquiterpenes; Isodihydroagarofuran; Cyanobacterium; Insecticide

Published in

Zeitschrift fur Naturforschung C
2009, volume: 64, number: 1-2, pages: 49-55

Authors' information

Höckelmann, Claudia
University of Zürich
Becher, Paul G (Becher, Paul)
University of Zürich
von Reuss, Stephan H.
University of Hamburg
Jüttner, Friedrich
University of Zürich

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