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Research article2003Peer reviewed

Differential effect of insulin-like growth factor I on in vitro gonadotropin subunits expression in Atlantic salmon

Schmitz, M


In the present study a serum-free primary culture of pituitary cells was used to study the direct effect of insulin-like growth factors (IGFs) on gonadotropin gene expression in immature Atlantic salmon. Treatment with IGF I increased the expression of the luteinizing hormone (LH) beta subunit in a dose-dependent manner. IGF I and IGF II had similar potencies, but insulin was less effective in stimulating LH-beta subunit expression. On the other hand, IGFs or insulin had no effect on the expression of the follicle-stimulating hormone (FSH) beta-subunit. The results indicate that the stimulatory effect of IGF I on LH synthesis is exerted through a specific increase of the transcription level of the LH beta subunit

Published in

Fish Physiology and Biochemistry
2003, Volume: 28, number: 1-4, pages: 105-106

      SLU Authors

    • Schmitz, Monica

      • Department of Aquaculture, Swedish University of Agricultural Sciences

    UKÄ Subject classification

    Fish and Aquacultural Science

    Publication identifier


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