Abstract

High levels of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), mono- and non-ortho-polychlorinated biphenyls (PCBs), and polybrominated dibenzo-p-dioxins (PBDDs) are found in fish from coastal areas in the Baltic Sea, which may cause ecotoxicological effects. To increase our understanding of the persistency of the emerging pollutants polybrominated dibenzo-p-dioxins and dibenzofurans (PBDD/Fs), fish feed was spiked with 21 PBDD/Fs, 17 PCDD/Fs, and 30 PCBs and fed to zebrafish (Danio rerio). Concentrations in fish and eggs were examined during a 6- or 12-week uptake period, and a 6-week elimination period. Steady-state was reached for 2-, 3-, 7-, and/or 8-substituted tri- and tetra-BDD/Fs; 2,3,7,8-tetra-BDD (2,3,7,8-TeBDD) was the most strongly retained. Steady-state was not reached for tetra- to hexa-CDDs. Non-2,3,7,8 congeners showed little or no retention. Most PCBs had high retention and did not reach steady state. Half-lives decreased in the order PCBs?>?PCDD/Fs?>?PBDD/Fs. Concentrations of 2,3,7,8-substituted penta- to octa-CDD/Fs decreased with their degree of chlorination, suggesting that the rate-limiting factor for uptake is low bioavailability. Maternal transfer was observed for all retained compounds, with most transfer factors <1, indicating that transfer rates are affected by the poor water solubility of the compounds. The limited retention of the major PBDD congeners found in Baltic Sea fish suggests that they are exposed to high or very high concentrations via either food or water. Environ. Toxicol. Chem. 2012;31:804812. (c) 2012 SETAC

Keywords

Polybrominated dibenzo-p-dioxins; Dietary uptake; Metabolism; Maternal transfer; Zebrafish

Published in

Environmental Toxicology and Chemistry
2012, Volume: 31, number: 4, pages: 804-812
Publisher: WILEY-BLACKWELL

SLU Authors

• Norman Haldén, Anna

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Norrgren, Leif

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

Sustainable Development Goals

SDG6 Ensure availability and sustainable management of water and sanitation for all
SDG3 Ensure healthy lives and promote well-being for all at all ages


UKÄ Subject classification

Pathobiology


Publication identifier

DOI: https://doi.org/10.1002/etc.1750

Permanent link to this page (URI)

https://res.slu.se/id/publ/42991