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Research article - Peer-reviewed, 2010

Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages

Zavialov, Andrey; Gracia, Eduard; Glaichenhaus, Nicolas; Franco, Rafael; Zavialov, Anton; Lauvau, Gregorie; Zavialov, Anton


ADAs play a pivotal role in regulating the level of adenosine, a signaling molecule controlling a variety of cellular responses by binding to and activating four ADRs. Two enzymes, ADA1 and ADA2, are known to possess ADA activity in humans. Although the structure of ADA1 and its role in lymphocytic activation have been known for a long time, the structure and function of ADA2, a member of ADGF, remain enigmatic. Here, we found that ADA2 is secreted by monocytes undergoing differentiation into macrophages or DCs and that it binds to the cell surface via proteoglycans and ADRs. We demonstrate that ADA1 and ADA2 increase the rate of proliferation of monocyte-activated CD4(+) T cells independently of their catalytic activity. We also show that ADA2 induces T cell-dependent differentiation of monocytes into macrophages and stimulates macrophage proliferation. Our discovery of the growth factor-like activity of ADA2 explains clinical observations and suggests that this enzyme could be used as a drug candidate to modulate the immune responses during inflammation and cancer. J. Leukoc. Biol. 88: 279-290; 2010.


innate immunity; adaptive immunity; development

Published in

Journal of Leukocyte Biology
2010, volume: 88, number: 2, pages: 279-290

Authors' information

Zavialov, Andrey
Gracia, Eduard
Glaichenhaus, Nicolas
Franco, Rafael
Zavialov, Anton
Swedish University of Agricultural Sciences, Department of Molecular Biology
Lauvau, Gregorie
Zavialov, Anton

Sustainable Development Goals

SDG3 Good health and wellbeing

UKÄ Subject classification

Cell Biology

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