Abstract

Investigation of 12 Irish setter puppies from six litters with severe recurrent infections, neutrophilia and low body weight revealed a leucocyte adhesion protein deficiency with a total lack of CD11b and CD 18. Their neutrophil function was severely impaired with a totally absent capacity to ingest C3b-opsonized particles, a significantly impaired capacity to ingest IgG-opsonized particles and significantly diminished adherence to nylon wool when compared with neutrophils from healthy control dogs. The chemiluminescence of patient neutrophils activated by C3b-opsonized particles was, consequently, significantly decreased compared with that of control neutrophils, while the respiratory burst assayed by phorbolmyristate acid (PMA) stimulated nitroblue tetrazolium (NBT)-reduction was normal in the patient group. Random migration and chemotactic responses of patient and control neutrophils, were similar.The etiology, pathogenesis and clinical manifestations of the Irish setter leucocyte adhesion deficiency were similar to that of the leucocyte adhesion deficiency in humans.

Published in

Veterinary Immunology and Immunopathology
1992, Volume: 32, number: 3-4, pages: 261-280
Publisher: ELSEVIER SCIENCE BV

SLU Authors

• Trowald-Wigh, Gunilla

  • Department of Medicine and Surgery, Swedish University of Agricultural Sciences
    

• Johannisson, Anders

  • Department of Pathology, Swedish University of Agricultural Sciences
    
  • Uppsala University

• Norrgren, Leif

  • Department of Pathology, Swedish University of Agricultural Sciences
    

• Hård af Segerstad, Carl

  • Department of Pathology, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Clinical Science


Publication identifier

DOI: https://doi.org/10.1016/0165-2427(92)90050-Z

Permanent link to this page (URI)

https://res.slu.se/id/publ/43509