Research article - Peer-reviewed, 2012
Coherent estimates of genetic effects with missing information
Nettelblad, Carl; Pino-Querido, Ania; Álvarez-Castro, José; Carlborg, ÖrjanAbstract
Genetic effect estimates for loci detected in quantita- tive trait locus (QTL) mapping experiments depend upon two factors. First, they are parameterizations of the genotypic values determined by the model of ge- netic effects. Second, they are consequently also af- fected by the regression method used to estimate the genotypic values from the observed marker genotypes and phenotypes. There are two common causes for marker-genotype data to be incomplete in those ex- periments—missing marker-genotypes and within in- terval mapping. Different regression methods tend to differ in how this missing information is represented and handled. In this communication we explain why the estimates of genetic effects of QTL obtained using standard regression methods are not coherent with the model of genetic effects and indeed show intrinsic inconsistencies when there is incomplete genotype information. We then describe the interval mapping by imputations (IMI) regression method and prove that it overcomes those problems. A numerical exam- ple is used to illustrate the use of IMI and the conse- quences of using current methods of choice. IMI en- ables researchers to obtain estimates of genetic effects that are coherent with the model of genetic effects used, despite incomplete genotype information. Fur- thermore, because IMI allows orthogonal estimation of genetic effects, it shows potential performance ad- vantages for being implemented in QTL mapping tools.Keywords
Genetic Effects; Missing Genotypes; Orthogonal Estimation; QTL AnalysisPublished in
Open Journal of Genetics2012, volume: no vol., number: 2, pages: 31-38
Authors' information
Nettelblad, Carl
Pino-Querido, Ania
Álvarez-Castro, José (Álvarez-Castro, José)
Swedish University of Agricultural Sciences, Department of Animal Breeding and Genetics
Carlborg, Örjan
Swedish University of Agricultural Sciences, Department of Clinical Sciences
UKÄ Subject classification
Genetics
Publication Identifiers
DOI: https://doi.org/10.4236/ojgen.2012.21003
URI (permanent link to this page)
https://res.slu.se/id/publ/43562