Hedhammar, My
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Research article2009Peer reviewedOpen access
Tissue Response to Subcutaneously Implanted Recombinant Spider Silk: An in Vivo Study
Fredriksson, Camilla; Hedhammar, My; Feinstein, Ricardo E; Nordling, Kerstin; Kratz, Gunnar; Johansson, Jan; Huss, Fredrik; Rising, Anna
Abstract
Spider silk is an interesting biomaterial for medical applications. Recently, a method for production of recombinant spider silk protein (4RepCT) that forms macroscopic fibres in physiological solution was developed. Herein, 4RepCT and Mersilk(TM) (control) fibres were implanted subcutaneously in rats for seven days, without any negative systemic or local reactions. The tissue response, characterised by infiltration of macrophages and multinucleated cells, was similar with both fibres, while only the 4RepCT-fibres supported ingrowth of fibroblasts and newly formed capillaries. This in vivo study indicates that 4RepCT-fibres are well tolerated and could be used for medical applications, e. g., tissue engineering.
Keywords
spider silk; recombinant; biocompatibility; in vivo
Published in
Materials
2009, Volume: 2, number: 4, pages: 1908-1922
Publisher: MDPI AG
Nordling, Kerstin
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Johansson, Jan
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Rising, Anna
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
SLU Authors
UKÄ Subject classification
Medical Materials
Publication identifier
DOI: https://doi.org/10.3390/ma2041908
Permanent link to this page (URI)
https://res.slu.se/id/publ/43689