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Conference abstract2012

Clinical and histological response to topical application of Xxterra® and Aldara® on healthy horse skin

Bergvall, Kerstin

Abstract

The objective of this study was to evaluate the clinical and histological effects of topical applications of sanguinarine and zinc sulphate (Xxterra Uppsala, Sweden) and imiquimod (Aldara Solna, Sweden) to healthy horse skin. Xxterra and Aldara however, there is no report of their effect on healthy horse skin. Two healthy standardbred mares, 13 and 16 years old, were clipped on each side of the neck and biopsied. One week later, 0.5 mL of Aldara Xxterra side of the neck, respectively, for 3 weeks. Aldara applied three times weekly according to the protocol used in a previous sarcoid treatment study and Xxterra daily for 5 days, then twice weekly according to the manufacturer’s recommendations. The lesions were photographed and evaluated daily. One week after discontinuing treatment the areas were biopsied and sent blinded to a pathologist. Both horses developed similar degree of eroded, crusted lesions with moderate swelling and pain when touched. Histopathology revealed orthokeratotic hyperkeratosis and epidermal hyperplasia and a diffuse lymphocytic infiltration in the superficial dermis in both treatments. Fibrosis of the deep dermis was seen in Xxterra adventitia of subcutaneous vessels was noticed in Aldara; N-Vet AB,; Meda AB,, have been used to treat equine sarcoids; and were applied to a 3 cm diameter area, on each was once treated skin and oedema of the tunica treated skin. In conclusion, Xxterra and Aldara applied to healthy horse skin initiated an inflammatory response characterised clinically by crusting, swelling and pain and histologically by a lymphocytic reaction, fibrosis (Xxterra) and vessel oedema (Aldara).

Published in

Veterinary Dermatology
2012, Volume: 23, number: Supplement s1, pages: 51-51
Publisher: bla

Conference

7th World Congress of Veterinary Dermatology