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Research article - Peer-reviewed, 2005

IgG avidity pattern in cattle after ingestion of Neospora caninum oocysts

Bjorkman C, Gondim LFP, Naslund K, Trees AJ, McAllister MM

Abstract

The avidity (functional affinity) of specific antibodies are being used to estimate duration of bovine Neospora caninum infection. Here, we report for the first time the avidity pattern in cattle orally inoculated with N. caninum oocysts. In all, 16 pregnant cows and 7 calves were administered N. caninum oocysts. In the cows, the avidity increased during the early course of infection. In all but one, the avidity was <= 35 during the first 6 weeks after infection and no cow had an avidity value > 50 until week 9. The calves were sampled either week 6 (n = 3) or week 9 (n = 9) after infection, and by then had avidities between 2 and 17. The results are in agreement with results from previous investigations of naturally infected cattle, and calves that were experimentally infected with tachyzoites. They further validate the ability of the N. caninum iscom avidity ELISA to accurately assess the duration of infection. (c) 2004 Elsevier B.V. All rights reserved

Published in

Veterinary Parasitology
2005, volume: 128, number: 3-4, pages: 195-200
Publisher: ELSEVIER SCIENCE BV

Authors' information

Swedish University of Agricultural Sciences, Department of Clinical Sciences
Trees, A J
Näslund, K
Gondim, L F P
McAllister, M M

Publication Identifiers

DOI: https://doi.org/10.1016/j.vetpar.2004.11.030

URI (permanent link to this page)

https://res.slu.se/id/publ/4456