Support of Concept That Migrating Progenitor Cells From Stem Cell Niches Contribute to Normal Regeneration of the Adult Mammal Intervertebral Disc A Descriptive Study in the New Zealand White Rabbit

Henriksson, Helena Barreto; Svala, Emilia; Skiöldebrand, Eva; Lindahl, Anders; Brisby, Helena

doi:10.1097/BRS.0b013e318231c2f7

Research article2012Peer reviewed

Support of Concept That Migrating Progenitor Cells From Stem Cell Niches Contribute to Normal Regeneration of the Adult Mammal Intervertebral Disc A Descriptive Study in the New Zealand White Rabbit

Henriksson, Helena Barreto; Svala, Emilia; Skiöldebrand, Eva; Lindahl, Anders; Brisby, Helena

Abstract

Conclusion. The results suggest a cellular MR from the IVD stem cell niche toward the annulus fibrosus and the inner parts of the IVD. These findings may be of importance for understanding IVD regenerative mechanisms and for future development of biological treatment strategies.

Keywords

disc regeneration; cell migration; stem cell niches; intervertebral disc; in vivo labeling; BrdU; GDF5

Published in

Spine
2012, Volume: 37, number: 9, pages: 722-732
Publisher: LIPPINCOTT WILLIAMS & WILKINS

SLU Authors

Svala, Emilia
- Department of Animal Biosciences, Swedish University of Agricultural Sciences

Skiöldebrand, Eva
- Department of Animal Biosciences, Swedish University of Agricultural Sciences

UKÄ Subject classification

Neurosciences

Publication identifier

DOI: https://doi.org/10.1097/BRS.0b013e318231c2f7

Permanent link to this page (URI)

https://res.slu.se/id/publ/45616