Abstract

The pharmacokinetic properties of clemastine were investigated in six healthy dogs and compared with the effect of the drug recorded as inhibition of wheal formation induced by intradermal injections of histamine. Clemastine clearance was high (median: 2.1 L h(-1) kg(-1)) and the volume of distribution large (13.4 L kg(-1)). The half-life after intravenous administration was 3.8 h and the plasma protein binding level in vitro was 98%. After oral administration, the bioavailability was only 3%. Given intravenously, clemastine (0.1 mg kg(-1)) inhibited wheal formation completely for 7 h, whereas the effect after oral administration (0.5 mg kg(-1)) was minor. The data show that most dosage regimens suggested in the literature for the oral administration of clemastine to dogs are likely to give too low a systemic exposure of the drug to allow effective therapy

Keywords

clemastine; dog

Published in

Veterinary Dermatology
2004, Volume: 15, number: 3, pages: 152-158
Publisher: BLACKWELL PUBLISHING LTD

SLU Authors

• Bergvall, Kerstin

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

• Törneke, Karolina

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Hamlin, Helene

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Animal and Dairy Science
Veterinary Science


Publication identifier

DOI: https://doi.org/10.1111/j.1365-3164.2004.00367.x

Permanent link to this page (URI)

https://res.slu.se/id/publ/4572