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Research article2010Peer reviewedOpen access

Genetic Variants and Disease-Associated Factors Contribute to Enhanced Interferon Regulatory Factor 5 Expression in Blood Cells of Patients With Systemic Lupus Erythematosus

Feng, D; Stone, Rivka C.; Eloranta, Maija-Leena; Sangster-Guity, N; Nordmark, Gunnel; Sigurdsson, Snaevar; Wang, Chuan; Alm, Gunnar; Syvänen, Ann-Christine; Rönnblom, Lars; Barnes, Betsy J.


Conclusion. This study provides the first formal proof that IRF-5 expression and alternative splicing are significantly up- regulated in primary blood cells of patients with SLE. Furthermore, the risk haplotype is associated with enhanced IRF-5 transcript and protein expression in patients with SLE.

Published in

Arthritis and Rheumatism
2010, Volume: 62, number: 2, pages: 562-573

      UKÄ Subject classification

      Rheumatology and Autoimmunity

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