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Review article2010Peer reviewedOpen access

Mast cell proteases: multifaceted regulators of inflammatory disease

Pejler, Gunnar; Rönnberg, Elin; Waern, Ida; Wernersson, Sara

Abstract

Mast cells (MCs) are currently receiving increased attention among the scientific community, largely because of the recent identification of crucial functions for MCs in a variety of disorders. However, it is in many cases not clear exactly how MCs contribute in the respective settings. MCs express extraordinarily high levels of a number of proteases of chymase, tryptase, and carboxypeptidase A type, and these are stored in high amounts as active enzymes in the MC secretory granules. Hence, MC degranulation leads to the massive release of fully active MC proteases, which probably have a major impact on any condition in which MC degranulation occurs. Indeed, the recent generation and evaluation of mouse strains lacking individual MC proteases have indicated crucial contributions of these to a number of different disorders. MC proteases may thus account for many of the effects ascribed to MCs and are currently emerging as promising candidates for treatment of MC-driven disease. In this review, we discuss these findings. (Blood.2010;115(24):4981-4990)

Published in

Blood
2010, Volume: 115, number: 24, pages: 4981-4990 Publisher: AMER SOC HEMATOLOGY