- Karolinska Institute
Omri, Snir; Widhe, Mona; Hermansson, Monika; von Spee, Caroline; Lindberg, Johan; Hensen, Sanne; Lundberg, Karin; Engström, Åke; Venables, Patrick J. W.; Toes, Rene E. M.; Holmdahl, Rikard; Klareskog, L; Malmstrom, Vivianne
Conclusion. MCV and CCP positivity represent a similar subset of RA patients, whereas ACPAs with different fine specificities fall into subgroups of anti-CCP+/anti-MCV+ patients. The levels of all specific ACPAs were elevated in synovial fluid, suggesting that there is local antibody production and/or retention of ACPAs at the site of inflammation governed by RA-predisposing genes.
Arthritis and Rheumatism
2010, Volume: 62, number: 1, pages: 44-52
Rheumatology and Autoimmunity