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Research article - Peer-reviewed, 2010

Antibodies to Several Citrullinated Antigens Are Enriched in the Joints of Rheumatoid Arthritis Patients

Omri, Snir; Widhe, Mona; Hermansson, Monika; von Spee, Caroline; Lindberg, Johan; Hensen, Sanne; Lundberg, Karin; Engström, Åke; Venables, Patrick J. W.; Toes, Rene E. M.; Holmdahl, Rikard; Klareskog, L; Malmstrom, Vivianne


Conclusion. MCV and CCP positivity represent a similar subset of RA patients, whereas ACPAs with different fine specificities fall into subgroups of anti-CCP+/anti-MCV+ patients. The levels of all specific ACPAs were elevated in synovial fluid, suggesting that there is local antibody production and/or retention of ACPAs at the site of inflammation governed by RA-predisposing genes.

Published in

Arthritis and Rheumatism
2010, Volume: 62, number: 1, pages: 44-52
Publisher: WILEY-LISS

    SLU Authors

    • Widhe, Mona

      • Karolinska Institute

    UKÄ Subject classification

    Rheumatology and Autoimmunity

    Publication Identifiers


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