Genome Sequence, Comparative Analysis, and Population Genetics of the Domestic Horse

Lindgren, Gabriella; Adelson, D.L.; Andersson, Leif; Antczak, D.F.; Bellone, R.R.; Blöcker, H.; Broad Institute Genome Sequencing Platform,; Broad Institute Whole Genome Assembly Team,; Chowdhary, B.P.; Coleman, S.J.; Della Valle, G.; Edgar, R.C.; Fryc, S.; Garber, M.; Giulotto, E.; Gnerre, S.; Jurka, J.; Kiialainen, A.; Lear, T.L.; MacLeod, J.N.; Magnani, E.; Mauceli, E.; Murray, J.; Nergadze, S.G.; Onofrio, R.; Pedroni, S.; Piras, M.F.; Raison, J.M.; Raudsepp, T.; Rocchi, M.; Röed, K.H.; Ryder, O.A.; Searle, S.; Skow, L.; Syvänen, A.C.; Vogel, J.; White, J.R.; Zoli, M.; Wade, C.M.; Bailey, E.; Lander, E.S.; Hill, E.W.; Imsland, F.; Guérin, G.; Liu, J.; Swinburne, J.E.; Mickelson, J.R.; Lindblad-Toh, K.; Vaudin, M.; Zody, M.C.; Penedo, M.C.T.; Binns, M.M.; Distl, O.; Sigurdsson, S.; Valberg, S.J.; Biagi, T.; Hasegawa, T.; Leeb, T.; Sharpe, T.; Tozaki, T.

doi:10.1126/science.1178158

Research article2009Peer reviewedOpen access

Genome Sequence, Comparative Analysis, and Population Genetics of the Domestic Horse

Lindgren, Gabriella; Adelson, D.L.; Andersson, Leif; Antczak, D.F.; Bellone, R.R.; Blöcker, H.; Broad Institute Genome Sequencing Platform, ; Broad Institute Whole Genome Assembly Team, ; Chowdhary, B.P.; Coleman, S.J.; Della Valle, G.; Edgar, R.C.; Fryc, S.; Garber, M.; Giulotto, E.; Gnerre, S.; Jurka, J.; Kiialainen, A.; Lear, T.L.; MacLeod, J.N.;
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Abstract

We report a high-quality draft sequence of the genome of the horse ( Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.

Published in

Science
2009, Volume: 326, number: 5954, pages: 865-867
Publisher: AMER ASSOC ADVANCEMENT SCIENCE

SLU Authors

Lindgren, Gabriella
- Department of Animal Biosciences, Swedish University of Agricultural Sciences

UKÄ Subject classification

Veterinary Science
Animal and Dairy Science

Publication identifier

DOI: https://doi.org/10.1126/science.1178158

Permanent link to this page (URI)

https://res.slu.se/id/publ/49149