Abstract

Neuronal ceroid lipofusinoses (NCL) are a group of lethal inherited progressive neurodegenerative disorders and more than 20 different genes have been associated with these diseases. In Australian Devon cattle there is strong evidence that NCL is caused by a single nucleotide insertion in the CLN5 gene (c.662dupG). The aim of the present study was to estimate the frequency of the disease-causing allele in the Australian Devon cattle population. Samples from 300 randomly selected animals were requested, 190 samples were received and genotyped using a previously described DNA test. All animals were homozygous normal and the allele frequency of NCL in Australian Devon cattle was therefore estimated to be zero.

Published in

Proceedings of the Association for the Advancement of Animal Breeding and Genetics
2013, Volume: 20, pages: 203-206 Title: Proceedings of the twentieth conference. Association for the Advancement of Animal Breeding and Genetics AAABG
ISBN: 978-0-473-26056-9
Publisher: Association for the Advancement of Animal Breeding and Genetics

Conference

The AAABG 20th Conference (Association for the Advancement of Animal Breeding and Genetics)

SLU Authors

• Jonas, Elisabeth

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    
  • University of Sydney

UKÄ Subject classification

Genetics and Breeding


Permanent link to this page (URI)

https://res.slu.se/id/publ/51346