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Research article - Peer-reviewed, 2013

Clinical efficacy and safety of a water-soluble micellar paclitaxel (Paccal Vet) in canine mastocytomas

Rivera, Patricio; Åkerlund Denneberg, Nanna; Bergvall, Kerstin; Kessler, M; Rowe, André; Willmann, M; Persson, G; Kastengren Fröberg, Gunilla; Westberg, Sara; Von Euler, Henrik


Objective To determine the clinical efficacy and safety of a cremophor-free formulation of paclitaxel (Paccal Vet, Oasmia Pharmaceuticals) in dogs with mast cell tumours. Methods Paccal Vet was administered at a median dose of 145 (range, 135 to 150) mg/m2intravenously once every 21 days for three cycles to 29 dogs with macroscopic grade 2 or 3 mast cell tumour. Efficacy was assessed by tumour response (Response Evaluation Criteria in Solid Tumours version 1.0) and performance status score. Progression-free survival, quality of life and safety/adverse events were also evaluated. Clinical safety was assessed by clinicopathological analyses and recording of adverse events. Results Complete or partial response was observed in 59% of dogs. Performance status score remained constant or improved for 20 dogs and decreased by one grade for 9 dogs. Median time to progression was 247 (range, 42 to 268) days. Expected, transient frequently subclinical adverse events (primarily grade 3/4 neutropenia and grade 1/2 leukopenia) were observed in the majority of dogs. Nine dogs were euthanased and one dog died due to disease progression. Clinical Significance Paccal Vet appears to be a clinically safe and effective treatment for canine mast cell tumours. Further controlled confirmatory investigation is warranted.

Published in

Journal of Small Animal Practice
2013, volume: 54, number: 1, pages: 20-27

Authors' information

Rivera, Patricio
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Åkerlund Denneberg, Nanna
Swedish University of Agricultural Sciences, Department of Clinical Sciences
DjurAkuten Stockholm
Kessler, M
Rowe, André
Willmann, M
Persson, G
Kastengren Fröberg, Gunilla
Westberg, Sara (Saellström, Sara)
Swedish University of Agricultural Sciences, University Animal Hospital
Von Euler, Henrik (Rönnberg, Henrik)
Swedish University of Agricultural Sciences, Department of Clinical Sciences

UKÄ Subject classification

Clinical Science

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