Research article - Peer-reviewed, 2014
Glioma-derived macrophage migration inhibitory factor (MIF) promotes mast cell recruitment in a STAT5-dependent manner
Põlajeva, Jelena; Lundequist, Anders; Pejler, Gunnar; Tchougounova, ElenaAbstract
Further, both glioma-conditioned media and purified MIF promoted differential phosphorylation of a number of signaling molecules, including signal transducer and activator of transcription 5 (STAT5), in MCs. Inhibition of pSTAT5 signaling significantly attenuated the migration of MCs toward glioma cell-conditioned medium shown to contain MIF. In addition, analysis of tissue microarrays (TMAs) of high-grade gliomas revealed a direct correlation between the level of pSTAT5 in MCs and the level of MIF in the medium. In conclusion, these findings indicate the important influence of signaling cascades involving MIF and STAT5 on the recruitment of MCs to gliomas. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.Keywords
Mast cell; Glioma; MIF; pSTAT5Published in
Molecular Oncology2014, volume: 8, number: 1, pages: 50-58
Publisher: ELSEVIER SCI LTD
Authors' information
Põlajeva, Jelena
Uppsala University
Lundequist, Anders
Swedish University of Agricultural Sciences, Department of Anatomy, Physiology and Biochemistry (AFB)
Swedish University of Agricultural Sciences, Department of Anatomy, Physiology and Biochemistry (AFB)
Tchougounova, Elena
UKÄ Subject classification
Immunology in the medical area
Neurosciences
Publication Identifiers
DOI: https://doi.org/10.1016/j.molonc.2013.09.002
URI (permanent link to this page)
https://res.slu.se/id/publ/52766