Glioma-derived macrophage migration inhibitory factor (MIF) promotes mast cell recruitment in a STAT5-dependent manner

Põlajeva, Jelena; Lundequist, Anders; Pejler, Gunnar; Tchougounova, Elena

doi:10.1016/j.molonc.2013.09.002

Research article - Peer-reviewed, 2014

Glioma-derived macrophage migration inhibitory factor (MIF) promotes mast cell recruitment in a STAT5-dependent manner

Põlajeva, Jelena; Lundequist, Anders; Pejler, Gunnar; Tchougounova, Elena

Abstract

Further, both glioma-conditioned media and purified MIF promoted differential phosphorylation of a number of signaling molecules, including signal transducer and activator of transcription 5 (STAT5), in MCs. Inhibition of pSTAT5 signaling significantly attenuated the migration of MCs toward glioma cell-conditioned medium shown to contain MIF. In addition, analysis of tissue microarrays (TMAs) of high-grade gliomas revealed a direct correlation between the level of pSTAT5 in MCs and the level of MIF in the medium. In conclusion, these findings indicate the important influence of signaling cascades involving MIF and STAT5 on the recruitment of MCs to gliomas. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Keywords

Mast cell; Glioma; MIF; pSTAT5

Published in

Molecular Oncology
2014, volume: 8, number: 1, pages: 50-58
Publisher: ELSEVIER SCI LTD

Authors' information

Põlajeva, Jelena

Uppsala University

Lundequist, Anders

Swedish University of Agricultural Sciences, Department of Anatomy, Physiology and Biochemistry (AFB)

Pejler, Gunnar

Swedish University of Agricultural Sciences, Department of Anatomy, Physiology and Biochemistry (AFB)

Tchougounova, Elena

UKÄ Subject classification

Immunology in the medical area
Neurosciences

Publication Identifiers

DOI: https://doi.org/10.1016/j.molonc.2013.09.002

URI (permanent link to this page)

https://res.slu.se/id/publ/52766