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Research article2001Peer reviewed

Family 7 cellobiohydrolases from Phanerochaete chrysosporium: Crystal structure of the catalytic module of Cel7D (CBH58) at 1.32 angstrom resolution and homology models of the isozymes

Munoz, Ines G.; Ubhayasekera, Wimal; Henriksson, Hongbin; Szabo, Istvan; Pettersson, Göran; Johansson, Gunnar; Mowbray, Sherry; Ståhlberg, Jerry

Abstract

The Cel7D structure was used to model the products of the five other family 7 genes found in P. chrysosporium. The results suggest that at least two of these will have differences in specificity and possibly catalytic mechanism, thus offering some explanation for the presence of Cel7 isozymes in this species, which are differentially expressed in response to various growth conditions. (C) 2001 Academic Press.

Keywords

cellulase; cellulose; glycoside hydrolase; endoglucanase; Trichoderma reesei; homology modeling

Published in

Journal of Molecular Biology
2001, Volume: 314, number: 5, pages: 1097-1111
Publisher: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD

      SLU Authors

    • Munoz, Ines G.

      • Department of Molecular Biology, Swedish University of Agricultural Sciences

      • Ubhayasekera, Wimal

        • Department of Molecular Biology, Swedish University of Agricultural Sciences

          • Mowbray, Sherry

            • Department of Molecular Biology, Swedish University of Agricultural Sciences

            • Ståhlberg, Jerry

              • Department of Molecular Biology, Swedish University of Agricultural Sciences

            UKÄ Subject classification

            Biochemistry and Molecular Biology
            Structural Biology
            Renewable Bioenergy Research

            Publication identifier

            DOI: https://doi.org/10.1006/jmbi.2000.5180

            Permanent link to this page (URI)

            https://res.slu.se/id/publ/53158