Uncertainty estimation in dynamic contrast-enhanced MRI

Abstract

Using dynamic contrast-enhanced MRI (DCE-MRI), it is possible to estimate pharmacokinetic (PK) parameters that convey information about physiological properties, e.g., in tumors. In DCE-MRI, errors propagate in a nontrivial way to the PK parameters. We propose a method based on multivariate linear error propagation to calculate uncertainty maps for the PK parameters. Uncertainties in the PK parameters were investigated for the modified Kety model. The method was evaluated with Monte Carlo simulations and exemplified with in vivo brain tumor data. PK parameter uncertainties due to noise in dynamic data were accurately estimated. Noise with standard deviation up to 15% in the baseline signal and the baseline T1 map gave estimated uncertainties in good agreement with the Monte Carlo simulations. Good agreement was also found for up to 15% errors in the arterial input function amplitude. The method was less accurate for errors in the bolus arrival time with disagreements of 23%, 32%, and 29% for Ktrans, ve, and vp, respectively, when the standard deviation of the bolus arrival time error was 5.3 s. In conclusion, the proposed method provides efficient means for calculation of uncertainty maps, and it was applicable to a wide range of sources of uncertainty. Magn Reson Med 69:9921002, 2013. (c) 2012 Wiley Periodicals, Inc.

Keywords

uncertainty estimation; dynamic contrast-enhanced-MRI; precision analysis; accuracy

Published in

Magnetic Resonance in Medicine
2013, volume: 69, number: 4, pages: 992-1002
Publisher: WILEY-BLACKWELL

SLU Authors

• Yu, Jun

  • Department of Forest Economics, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Medical Imaging
Probability Theory and Statistics

Publication identifier

• DOI: https://doi.org/10.1002/mrm.24328

Permanent link to this page (URI)

https://res.slu.se/id/publ/55980