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Review article2014Peer reviewedOpen access

Polyamines and programmed cell death

Moschou, Panagiotis Nikolaou; Roubelakis-Angelakis, K.A.

Abstract

Polyamines (PAs) have been considered as important molecules for survival. However, evidence reinforces that PAs are also implicated, directly or indirectly, in pathways regulating programmed cell death (PCD). Direct correlation of PAs with cell death refers to their association with particular biological processes, and their physical contact with molecules or structures involved in cell death. Indirectly, PAs regulate PCD through their metabolic derivatives, such as catabolic and interconversion products. Cytotoxic products of PA metabolism are involved in PCD cascades, whereas it remains largely elusive how PAs directly control pathways leading to PCD. In this review, we present and compare advances in PA-dependent PCD in animals and plants.

Keywords

Apoptosis; autophagy; cell cycle; cell death; development; oxidases; oxidative stress; polyamines; programmed cell death; spermidine

Published in

Journal of Experimental Botany
2014, Volume: 65, number: 5, pages: 1285-1296 Publisher: OXFORD UNIV PRESS

    Associated SLU-program

    SLU Plant Protection Network

    UKÄ Subject classification

    Biochemistry and Molecular Biology
    Developmental Biology

    Publication identifier

    DOI: https://doi.org/10.1093/jxb/ert373

    Permanent link to this page (URI)

    https://res.slu.se/id/publ/57530