Xia, Hongyan
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- National Veterinary Institute (SVA)
Abstract
The Chinese hog cholera lapinized virus (HCLV), also called the "Chinese strain" or "C-strain" of classical swine fever virus (CSFV), was developed in China in the 1950s. There are uncertainties about the genetic heterogeneity and origin of this vaccine virus. The objectives of this study were to investigate the genetic heterogeneity of the C-strain, for which nucleotide sequences have been submitted to GenBank from different laboratories, and to determine whether there is any evidence to support the hypothesis that the C-strain originated from the Shimen strain. Analysis of 150 nearly complete E2 gene sequences revealed that the C-strain clade includes several HCLV vaccine strains, cell-culture-adapted Riems strains, and viruses isolated from diseased pigs. The whole-genome phylogeny indicated that the ancestor of the C-strain was only distantly related to the Shimen strain. Therefore, there was no phylogenetic evidence to support the Shimen-origin hypothesis.
Published in
Archives of Virology
2011, volume: 156, number: 6, pages: 1041-1044
Publisher: SPRINGER WIEN
SLU Authors
Belak, Sandor
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- National Veterinary Institute (SVA)
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
UKÄ Subject classification
Animal and Dairy Science
Veterinary Science
Publication identifier
- DOI: https://doi.org/10.1007/s00705-011-0948-5
Permanent link to this page (URI)
https://res.slu.se/id/publ/57803