Abstract

Vertebrates engage in symbiotic associations with vast and complex microbial communities that colonize their gastrointestinal tracts. Recent advances have provided mechanistic insight into the important contributions of the gut microbiome to vertebrate biology, but questions remain about the evolutionary processes that have shaped symbiotic interactions in the gut and the consequences that arise for both the microbes and the host. Here we discuss the biological principles that underlie microbial symbiosis in the vertebrate gut and the potential of the development of mutualism. We then review phylogenetic and experimental studies on the vertebrate symbiont Lactobacillus reuteri that have provided novel insight into the ecological and evolutionary strategy of a gut microbe and its relationship with the host. We argue that a mechanistic understanding of the microbial symbiosis in the vertebrate gut and its evolution will be important to determine how this relationship can go awry, and it may reveal possibilities by which the gut microbiome can be manipulated to support health.

Keywords

vertebrate symbiont; microbiota; mutualism

Published in

Proceedings of the National Academy of Sciences
2011, Volume: 108, number: Supplement 1, pages: 4645-4652
Publisher: NATL ACAD SCIENCES

SLU Authors

• Roos, Stefan

  • Department of Molecular Sciences, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Food Science
Microbiology


Publication identifier

DOI: https://doi.org/10.1073/pnas.1000099107

Permanent link to this page (URI)

https://res.slu.se/id/publ/57815