Increasing the efficiency of variance component quantitative trait loci analysis by using reduced-rank identity-by-descent matrices

Abstract

Recent technological development in genetics has made large-scale marker genotyping fast and practicable, facilitating studies for detection of QTL in large general pedigrees. We developed a method that speeds up restricted maximum-likelihood (REML) algorithms for QTL analysis by simplifying the inversion of the variance-covariance matrix of the trait vector. The method was tested in an experimental chicken pedigree including 767 phenotyped individuals and 14 genotyped markers on chicken chromosome 1. The computation time in a chromosome scan covering 475 cM was reduced by 43% when the analysis was based on linkage only and by 72% when linkage disequilibrium information was included. The relative advantage of using our method increases with pedigree size, marker density, and linkage disequilibrium, indicating even greater improvements in the future.

Published in

Genetics
2007, Volume: 176, number: 3, pages: 1935-1938 Publisher: GENETICS

UKÄ Subject classification

Other Veterinary Science


Publication identifier

DOI: https://doi.org/10.1534/genetics.107.071977

Permanent link to this page (URI)

https://res.slu.se/id/publ/57916