Park, H B
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Research article2002Peer reviewed
Melanocortin-4 receptor (MC4R) genotypes have no major effect on fatness in a Large White x Wild Boar intercross
Park, H B; Carlborg, Örjan; Marklund, Stefan; Andersson, Leif
Abstract
The melanocortin-4 receptor (MC4R), a G-protein coupled receptor, is implicated in mediating the effect of leptin on food intake and energy balance. A previous candidate gene study reported an association between an MC4R missense mutation (Asp298Asn) and fatness, growth and feed intake in pigs. To assess this association further, we analysed the segregation of this missense mutation in relation to variation in fatness traits using a Wild Boar x Large White intercross. The Wild Boar and Large White founders were homozygous for different MC4R alleles. The MC4R was assigned to the expected region on pig chromosome 1. The statistical evaluation did not reveal any indication of a significant effect on fatness related traits in this pedigree.
Keywords
fatness; MC4R; pigs; quantitative trait loci
Published in
Animal Genetics
2002, volume: 33, number: 2, pages: 155-157
Publisher: BLACKWELL PUBLISHING LTD
SLU Authors
Carlborg, Örjan
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Marklund, Stefan
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Andersson, Leif
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
UKÄ Subject classification
Genetics and Breeding in Agricultural Sciences
Publication identifier
- DOI: https://doi.org/10.1046/j.1365-2052.2002.00824.x
Permanent link to this page (URI)
https://res.slu.se/id/publ/57918