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Research article2004Peer reviewedOpen access

Simultaneous search for multiple QTL using the global optimization algorithm DIRECT

Ljungberg, Kajsa; Holmgren, S.; Carlborg, Örjan

Abstract

Results: We have the previously known algorithm adapted DIRECT, to the problem of simultaneous mapping of multiple QTL. We have compared DIRECT with standard exhaustive search and a genetic algorithm previously used for QTL mapping in two dimensions. In all two- and three-QTL test cases, DIRECT accurately finds the global optimum two to four orders of magnitude faster than when using an exhaustive search, and one order of magnitude faster than when using the genetic algorithm. Thus, randomization testing for determining empirical significance thresholds for at least three QTL is made feasible by the use of DIRECT.

Published in

Bioinformatics
2004, volume: 20, number: 12, pages: 1887-1895
Publisher: OXFORD UNIV PRESS

SLU Authors

  • Carlborg, Örjan

    • The Roslin Institute

UKÄ Subject classification

Genetics and Genomics
Computer Science

Publication identifier

  • DOI: https://doi.org/10.1093/bioinformatics/bth175

Permanent link to this page (URI)

https://res.slu.se/id/publ/57924