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Research article - Peer-reviewed, 2011

Recommended Guidelines for Submission, Trimming, Margin Evaluation, and Reporting of Tumor Biopsy Specimens in Veterinary Surgical Pathology

Kamstock, Debra A.; Ehrhart, Eugene J.; Getzy, David; Bacon, Nicholas J.; Rasnick, Kenneth M.; Moroff, Scott D.; Liu, S.M.; Straw, Rod C.; McKnight, Christy A.; Amorim, Renée Laufer; Bienzle, Dorothee; Cassali, Geovanni Dantas; Cullen, John M.; Dennis, Michelle M.; Esplin, D. Glen; Foster, Robert A.; Goldschmidt, Michael H.; Gruber, Achim; Hellmén, Eva; Howerth, Elizabeth W.;
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Neoplastic diseases are typically diagnosed by biopsy and histopathological evaluation. The pathology report is key in determining prognosis, therapeutic decisions, and overall case management and therefore requires diagnostic accuracy, completeness, and clarity. Successful management relies on collaboration between clinical veterinarians, oncologists, and pathologists. To date there has been no standardized approach or guideline for the submission, trimming, margin evaluation, or reporting of neoplastic biopsy specimens in veterinary medicine. To address this issue, a committee consisting of veterinary pathologists and oncologists was established under the auspices of the American College of Veterinary Pathologists Oncology Committee. These consensus guidelines were subsequently reviewed and endorsed by a large international group of veterinary pathologists. These recommended guidelines are not mandated but rather exist to help clinicians and veterinary pathologists optimally handle neoplastic biopsy samples. Many of these guidelines represent the collective experience of the committee members and consensus group when assessing neoplastic lesions from veterinary patients but have not met the rigors of definitive scientific study and investigation. These questions of technique, analysis, and evaluation should be put through formal scrutiny in rigorous clinical studies in the near future so that more definitive guidelines can be derived.


surgical pathology; veterinary medicine; diagnostic technique and procedure; tissue section; tumor margins

Published in

Veterinary Pathology
2011, Volume: 48, number: 1, pages: 19-31

    UKÄ Subject classification

    Animal and Dairy Science
    Veterinary Science

    Publication identifier


    Permanent link to this page (URI)