Olsén, Lena
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Research article2011Peer reviewed
Pharmacokinetics and effects of cetirizine in horses with insect bite hypersensitivity
Olsen, Lena; Bondesson, Ulf; Brostrom, Hans; Olsson, Ulf; Mazogi, Behnaz; Sundqvist, Marie; Tjalve, Hans; Ingvast-Larsson, Carina
Abstract
Horses with insect bite hypersensitivity (IBH) have difficulty in completely avoiding allergens, so effective treatment options are required. A randomised, placebo controlled and double blinded field study was conducted to determine the pharmacokinetics and efficacy in reducing dermatitis of the antihistamine cetirizine given orally at 0.4 mg/kg twice daily for 3 weeks. The influence of protection blankets and stabling were also investigated.The estimated maximum plasma concentration (C(max)) and trough plasma concentration of cetirizine were 135 ng/mL and 18 ng/mL, respectively. There was no difference in dermatitis reduction between the treatment and placebo groups (P = 0.77). The findings indicated that cetirizine was of no apparent benefit in treating IBH at the dose rate tested. The use of blankets and stabling were shown to have favourable influence on the dermatitis (P < 0.05) and may be the preferred options to prevent this condition. (C) 2010 Elsevier Ltd. All rights reserved.
Keywords
Horse; Antihistamine; Cetirizine; Pharmacokinetics; Insect bite hypersensitivity
Published in
Veterinary Journal
2011, Volume: 187, number: 3, pages: 347-351
Publisher: ELSEVIER SCI LTD
Broström, Hans
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
Olsson, Ulf
- Department of Economics, Swedish University of Agricultural Sciences
- Department of Economics, Swedish University of Agricultural Sciences
Mazogi, Behnaz
- Department of Economics, Swedish University of Agricultural Sciences
- Department of Economics, Swedish University of Agricultural Sciences
Tjälve, Hans
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Ingvast Larsson, Carina
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
SLU Authors
UKÄ Subject classification
Veterinary Science
Animal and Dairy Science
Publication identifier
DOI: https://doi.org/10.1016/j.tvjl.2009.12.030
Permanent link to this page (URI)
https://res.slu.se/id/publ/60582