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Research article2009Peer reviewed

Tissue Doppler and Strain Imaging in Dogs with Myxomatous Mitral Valve Disease in Different Stages of Congestive Heart Failure

Tidholm, Anna; Bersås Ljungvall, Ingrid; Höglund, Katja; Bodegård Westling, Anna; Häggström, Jens

Abstract

BackgroundTissue Doppler imaging (TDI) including strain and strain rate (SR) assess systolic and diastolic myocardial function.HypothesisTDI, strain, and SR variables of the left ventricle (LV) and the interventricular septum (IVS) differ significantly between dogs with myxomatous mitral valve disease (MMVD) with and without congestive heart failure (CHF).AnimalsSixty-one dogs with MMVD with and without CHF. Ten healthy control dogs.MethodsProspective observational study.ResultsRadial motion: None of the systolic variables were altered and 3 of the diastolic velocities were significantly increased in dogs with CHF compared with dogs without CHF and control dogs. Longitudinal motion: 2 systolic velocities and 3 diastolic velocities were significantly increased in dogs with CHF compared with dogs without CHF and control dogs. Difference in systolic velocity time-to-peak between LV and IVS was significantly increased in dogs with MMVD with and without CHF compared with control dogs. In total, 11 (23%) of 48 TDI and strain variables differed significantly between groups. Left atrial to aortic ratio was positively correlated to early diastolic velocities, percentage increase in left ventricular internal diameter in systole was positively correlated to systolic and diastolic velocities, and mitral E wave to peak early diastolic velocity in the LV basal segment (E/Em) was positively correlated to radial strain and SR.Conclusions and Clinical ImportanceFew TDI and strain variables were changed in dogs with MMVD with and without CHF. Intraventricular dyssynchrony may be an early sign of MMVD or may be an age-related finding.

Keywords

Chronic valvular disease; Dyssynchrony; Myocardial velocity

Published in

Journal of Veterinary Internal Medicine
2009, Volume: 23, number: 6, pages: 1197-1207
Publisher: WILEY-BLACKWELL