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Research article2014Peer reviewedOpen access

Cytotoxic Illudalane Sesquiterpenes from the Wood-Decay Fungus Granulobasidium vellereum (Ellis & Cragin) Julich

Nord, Christina; Menkis, Audrius; Broberg, Anders

Abstract

Seven illudalane sesquiterpenes were obtained from the wood decomposing fungus Granulobasidium vellereum: granuloinden A, granuloinden B and dihydrogranuloinden, along with the previously known compounds radulactone, pterosin M, echinolactone A and D. Granuloinden B showed potent cytotoxic activity against the Huh7 and MT4 tumor cell lines (CC50 values of 6.7 and 0.15 mu M, respectively), whereas granuloinden A and dihydrogranuloinden had no or moderate activity.

Keywords

Granulobasidium vellereum; sesquiterpenes; illudalane; cytotoxic

Published in

Molecules
2014, Volume: 19, number: 9, pages: 14195-14203
Publisher: MDPI AG

      SLU Authors

    • Nord, Christina

      • The Department of Chemistry and Biotechnology, Swedish University of Agricultural Sciences

        • Broberg, Anders

          • The Department of Chemistry and Biotechnology, Swedish University of Agricultural Sciences

        UKÄ Subject classification

        Organic Chemistry
        Microbiology

        Publication identifier

        DOI: https://doi.org/10.3390/molecules190914195

        Permanent link to this page (URI)

        https://res.slu.se/id/publ/63281