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Research article - Peer-reviewed, 2014

Ligation of the spermatic cord in dogs with a self-locking device of a resorbable polyglycolic based co-polymer

Höglund, Odd; Ingman, Jessica; Södersten, Fredrik; Hansson, Kerstin; Borg, Niklas; Lagerstedt, Anne-Sofie

Abstract

Background: New surgical techniques are developed to enable a quicker, easier and safer surgery with reduced risk of complications and shortened time needed for recovery. A resorbable device, a self-locking loop, was designed for surgical ligation. The objective of this pilot study was to investigate the feasibility of ligating the spermatic cord with the device, its biocompatibility and long-term resorption in dogs. 
Results: The device was made of a block co-polymer (glycolide and trimethylene carbonate), manufactured by injection moulding and consisted of a flexible band running through a case with a locking mechanism. Ten devices were tested for ligation of the spermatic cords in five dogs admitted for routine neutering. The dogs were monitored by physical examination and ultrasonography of the site of ligation, area of spermatic cord and medial iliac lymph nodes regularly until no hyperechoic remnants of the device or acoustic shadowing or local tissue reactions were observed. Haemostasis of the spermatic cords was achieved with the devices. On ultrasonography the devices were seen as hyperechoic structures for 2 months after neutering causing acoustic shadowing for 1 month. The dogs were monitored for 3 - 5 months after surgery. Gradual decrease in echogenicity and final disappearance of the hyperechoic structures suggested resorption. Macroscopic and histological post mortem examinations were performed in one dog at 3 months after surgery. Post mortem examination showed a tissue reaction of a suture granuloma that was restricted in extent at site of the device. 
Conclusions: The results of this pilot study suggest biocompatibility and indicate that ligation of the spermatic cord is feasible with the device.

Keywords

Resorbable medical device; Bioabsorbable; Glycolide; Trimethylene carbonate; Block co-polymer; Castration; Ultrasonography; Replacement; Reduction; Refinement

Published in

BMC Research Notes
2014, volume: 7, article number: 825

Authors' information

Swedish University of Agricultural Sciences, Department of Clinical Sciences
Swedish University of Agricultural Sciences, University Animal Hospital
Swedish University of Agricultural Sciences, Department of Clinical Sciences
Borg, Niklas
Radi Medical Systems
Swedish University of Agricultural Sciences, Department of Clinical Sciences

UKÄ Subject classification

Surgery
Biomaterials Science

Publication Identifiers

DOI: https://doi.org/10.1186/1756-0500-7-825

URI (permanent link to this page)

https://res.slu.se/id/publ/64840