Research article - Peer-reviewed, 2014
Maxsim2-Real-time interactive simulations for computer-assisted teaching of pharmacokinetics and pharmacodynamics
Gabrielsson, Johan; Andersson, Kristoffer; Tobin, Gunnar; Ingvast Larsson, Carina; Jirstrand, MatsAbstract
We developed a computer program for use in undergraduate and graduate courses in pharmacology, pharmacokinetics and pharmacodynamics. This program can also be used in environmental and toxicological studies and preclinical simulation, to facilitate communication between modeling pharmacokineticists and project leaders or other decision-makers in the pharmaceutical industry. The program simulates the drug delivery and transport by means of (I) a six-compartment physiological pharmacokinetic flow model, (II) a system of traditional compartment models, or (III) a target-mediated drug disposition system. The program also can be used to simulate instantaneous equilibria between concentration and pharmacodynamic response, or as temporal delays between concentration and response. The latter is done by means of turnover models (indirect response models). Drug absorption, distribution, and elimination are represented by differential equations, which are described by organ and tissue volumes or other volumes of distribution, blood flows, clearance terms, and tissue-to-blood partition coefficients. The user can control and adjust these parameters by means of a slider in real time. By interactively changing the parameter values and simultaneously displaying the resulting concentration-time and/or response-time profiles, users can understand the major mechanisms that govern the disposition or the pharmacological response of the drug in the organism in real time. Schedule dependence is typically seen in clinical practice with a non-linear concentration-response relationship, and is difficult to communicate except via simulations. Here, we sought to illustrate the potential advantages of this approach in teaching pharmacology, pharmacokinetics, and pharmacodynamics to undergraduate pharmacy-, veterinary-, and medical students or to project teams in drug discovery/development. (c) 2014 The Authors. Published by Elsevier Ireland Ltd. All rights reserved.Keywords
Pharmacokinetics; Pharmacodynamics; Pharmacology training; Real time simulations; Interaction; VisualizationPublished in
Computer Methods and Programs in Biomedicine2014, volume: 113, number: 3, pages: 815-829
Authors' information
Gabrielsson, Johan
Swedish University of Agricultural Sciences, Department of Biomedical Science and Veterinary Public Health
Andersson, Kristoffer
Fraunhofer-Chalmers Centre
Tobin, Gunnar
University of Gothenburg
Ingvast Larsson, Carina
Swedish University of Agricultural Sciences, Department of Biomedical Science and Veterinary Public Health
Jirstrand, Mats
Fraunhofer-Chalmers Centre
Associated SLU-program
Cross-programme
UKÄ Subject classification
Pharmacology and Toxicology
Pharmaceutical Sciences
Publication Identifiers
DOI: https://doi.org/10.1016/j.cmpb.2013.12.006
URI (permanent link to this page)
https://res.slu.se/id/publ/66200