Gabrielsson, Johan
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Abstract
The increased emphasis on mechanistic and quantitative approaches in pharmacology presents new challenges to the design and analysis of mathematical models used in drug discovery. In this paper we present three of such challenges: (i) How to proceed when exposure data are scarce or plainly absent? Response versus time data for different doses are then the only source of information. (ii) The advent of biological (biologics) therapeutics has resulted in a new class of models which involve the interaction of drug and target. (iii) How to determine the impact of proteins at the target site on drug efficacy? We illustrate these challenges with three case studies.
Keywords
Pharmacokinetic-pharmacodynamic modelling; Target-mediated drug disposition; Plasma protein binding; Biophase; Dose-response-time analysis
Published in
Journal of Dynamics and Differential Equations
2015, volume: 27, number: 3-4, pages: 941-959
SLU Authors
Associated SLU-program
Cross-programme
UKÄ Subject classification
Pharmaceutical Sciences
Pharmacology and Toxicology
Publication identifier
- DOI: https://doi.org/10.1007/s10884-014-9377-y
Permanent link to this page (URI)
https://res.slu.se/id/publ/66203