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Abstract

As Arabidopsis thaliana has colonized a wide range of habitats across the world it is an attractive model for studying the genetic mechanisms underlying environmental adaptation. Here, we used public data from two collections of A. thaliana accessions to associate genetic variability at individual loci with differences in climates at the sampling sites. We use a novel method to screen the genome for plastic alleles that tolerate a broader climate range than the major allele. This approach reduces confounding with population structure and increases power compared to standard genome-wide association methods. Sixteen novel loci were found, including an association between Chromomethylase 2 (CMT2) and temperature seasonality where the genome-wide CHH methylation was different for the group of accessions carrying the plastic allele. Cmt2 mutants were shown to be more tolerant to heat-stress, suggesting genetic regulation of epigenetic modifications as a likely mechanism underlying natural adaptation to variable temperatures, potentially through differential allelic plasticity to temperature-stress.

Published in

PLoS Genetics
2014, volume: 10, number: 12, article number: e1004842
Publisher: PUBLIC LIBRARY SCIENCE

SLU Authors

UKÄ Subject classification

Evolutionary Biology
Genetics and Genomics
Bioinformatics and Computational Biology (Methods development to be 10203)

Publication identifier

  • DOI: https://doi.org/10.1371/journal.pgen.1004842

Permanent link to this page (URI)

https://res.slu.se/id/publ/66332