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Conference abstract - Peer-reviewed, 2014

Urine metabolite profiles in normal weight and overweight dogs

Söder, Josefin; Hagman, Ragnvi; Dicksved, Johan; Truelsen Lindåse, Sanna; Agback, Peter; Malmlöf, Kjell; Wernersson, Sara


Obesity in dogs is increasing and lifestyle-related diseases affect pets as well as pet owners. Urine metabolite profiles have earlier shown to be specific for both dog phenotypes and disease status. The objective of this study was to compare urine metabolite profiles in normal weight and overweight Labrador retrievers in fasting and postprandial samples. A total of 28 healthy intact male dogs aged 1-9 years with body condition score 4-8 (BCS, scale 1-9) were included in the study. Of these dogs 16 were classified as overweight (BCS 6-8) and 12 were classified as normal weight (BCS 4-5). An overnight fasting period of 14-17 hours was followed by collection of free catch morning urine. Thereafter each dog was fed a high energy diet containing half its daily maintenance requirements, based on body weight (BCS 4-5) and calculated ideal body weight (BCS 6-8).Three hours after the meal, a second urine sample was collected. Proton nuclear magnetic resonance spectroscopy combined with multivariate analysis was used for urine evaluation at both time points. Principal component analysis of metabolite profiles showed less variation among postprandial samples than among fasting samples and metabolite profiles changed with age irrespective of sampling time point. Moreover, a difference was seen between normal weight and overweight dogs in postprandial metabolite profiles. Therefore, identification of obesity-related urine metabolites appears possible and promise to provide further knowledge of metabolic alterations in dog obesity. In addition, urine biomarkers merit to be investigated as a potential diagnostic tool for obesity-related metabolic dysfunctions in dogs.

Published in

Journal of Veterinary Internal Medicine
2014, Volume: 28, number: 3, pages: 1090-1090
Publisher: American College of Veterinary Internal Medicine


American College of Veterinary Internal Medicine (ACVIM) Forum 2014