Abstract

Nuclear receptor 4a3 (Nr4a3) is a transcription factor implicated in various settings such as vascular biology and inflammation. We have recently shown that mast cells dramatically upregulate Nuclear receptor 4a3 upon activation, and here we investigated the functional impact of Nuclear receptor 4a3 on mast cell responses. We show that Nuclear receptor 4a3 is involved in the regulation of cytokine/chemokine secretion in mast cells following activation via the high affinity IgE receptor. Moreover, Nuclear receptor 4a3 negatively affects the transcript and protein levels of mast cell tryptase as well as the mast cell's responsiveness allergen. Together, these findings identify Nuclear receptor 4a3 as a novel regulator of mast cell function.

Published in

PLoS ONE
2014, Volume: 9, number: 2, article number: e89311
Publisher: PUBLIC LIBRARY SCIENCE

SLU Authors

• Garcia Faroldi, Gianni

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Rabelo Melo, Fabio

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Pejler, Gunnar

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Lundequist, Anders

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

Associated SLU-program

Future Animal Health and Welfare (until Jan 2017)


UKÄ Subject classification

Immunology


Publication identifier

DOI: https://doi.org/10.1371/journal.pone.0089311

Permanent link to this page (URI)

https://res.slu.se/id/publ/66590