Abstract

The effects on oxidative phosphorylation in rat mitochondria of some of the most common estrogenic isoflavones and zearalenone and their metabolites were assayed polarographically with an oxygen electrode. In general, the substances act as uncoupling agents. At 0-100-mu-M concentrations, biochanin A and formononetin exerted half to one-tenth the uncoupling activity of 2,4-dinitrophenol, while coumestrol and genistein caused lesser effects and daidzein and equol caused slight uncoupling. Zearalenone, alpha-zearalenol, and beta-zearalenol exerted uncoupling about equal with that of genistein. The isoflavones with highest uncoupling were likewise most effective as inhibitors of the respiratory chain and inhibit the electron transport at the same site as rotenone. The potential effect in vivo is discussed.

Published in

Journal of Agricultural and Food Chemistry
1991, Volume: 39, number: 4, pages: 736-739
Publisher: AMER CHEMICAL SOC

SLU Authors

• Lundh, Torbjörn

  • Department of Applied Animal Science and Welfare, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Agricultural Science


Publication identifier

DOI: https://doi.org/10.1021/jf00004a023

Permanent link to this page (URI)

https://res.slu.se/id/publ/67115