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Research article - Peer-reviewed, 2015

Cellulose nanofiber-titania nanocomposites as potential drug delivery systems for dermal applications

Galkina, Olga; Ivanov, V. K.; Agafonov, A.V.; Seisenbaeva, Gulaim; Kessler, Vadim

Abstract

In this work, new efficient drug delivery systems based on cellulose nanofiber-titania nanocomposites grafted with three different types of model drugs such as diclofenac sodium, penicillamine-D and phosphomycin were successfully synthesized and displayed distinctly different controlled long-term release profiles. Three different methods of medicine introduction were used to show that various interactions between TiO2 and drug molecules could be used to control the kinetics of long-term drug release. All synthesis reactions were carried out in aqueous media. The morphology, chemical structure and properties of the obtained materials were characterized by SEM, TEM and AFM microscopy, nanoparticle tracking analysis, X-ray diffraction, and TGA analysis. According to FT-IR and UV-Vis spectroscopy data, the titania binds to cellulose nanofibers via formation of ester bonds and to drug molecules via formation of surface complexes. The drug release kinetics was studied in vitro for diclofenac sodium and penicillamine-D spectrophotometrically and for phosphomycin using a radio-labeling analysis with P-33-marked ATP as a model phosphate-anchored biomolecule. The results demonstrated that the obtained nanocomposites could potentially be applied in transdermal drug delivery for anesthetics, analgesics and antibiotics.

Keywords

titania; cross-linking agent; cellulose; drug release; modification

Published in

Journal of Materials Chemistry B
2015, Volume: 3, number: 8, pages: 1688-1698
Publisher: Royal Society of Chemistry

      SLU Authors

    • Galkina, Olga

      • Russian Academy of Sciences
      • The Department of Chemistry and Biotechnology, Swedish University of Agricultural Sciences
      • Seisenbaeva, Gulaim

        • CaptiGel AB
        • The Department of Chemistry and Biotechnology, Swedish University of Agricultural Sciences
        • Kessler, Vadim

          • CaptiGel AB
          • The Department of Chemistry and Biotechnology, Swedish University of Agricultural Sciences

        UKÄ Subject classification

        Materials Chemistry
        Inorganic Chemistry
        Composite Science and Engineering

        Publication identifier

        DOI: https://doi.org/10.1039/c4tb01823k

        Permanent link to this page (URI)

        https://res.slu.se/id/publ/67129