Blomström, Anne-Lie
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- University of Glasgow
Research article2014Peer reviewedOpen access
NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery
Barry, Gerald; Varela, Mariana; Ratinier, Maxime; Blomström, Anne-Lie; Caporale, Marco; Seehusen, Frauke; Hahn, Kerstin; Schnettler, Esther; Baumgärtner, Wolfgang; Kohl, Alain; Palmarini, Massimo
Abstract
Bunyaviruses have evolved a variety of strategies to counteract the antiviral defence systems of mammalian cells. Here we show that the NSs protein of Schmallenberg virus (SBV) induces the degradation of the RPB1 subunit of RNA polymerase II and consequently inhibits global cellular protein synthesis and the antiviral response. In addition, we show that the SBV NSs protein enhances apoptosis in vitro and possibly in vivo, suggesting that this protein could be involved in SBV pathogenesis in different ways.
Published in
Journal of General Virology
2014, Volume: 95, pages: 1640-1646
Publisher: SOC GENERAL MICROBIOLOGY
SLU Authors
UKÄ Subject classification
Microbiology in the medical area
Public Health, Global Health, Social Medicine and Epidemiology
Publication identifier
DOI: https://doi.org/10.1099/vir.0.065425-0
Permanent link to this page (URI)
https://res.slu.se/id/publ/67996