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Research article, 2005

Analysis of Cross-Over Designs via Growth Curve Models

Åsenbladh, Nils; von, Rosen Dietrich


Models for repeated measures cross-over designs are defined in terms of growth curve models. In the paper two specific cross-over designs, called the AB:BA and ABAB:BABA design, are studied. The maximum likelihood estimators for the parameters are derived by utilizing the theory for growth curve models. A model with a structured dispersion matrix is defined for the AB:BA design, and a specific linear transformation is used to derive estimators in a convenient way. To illustrate numerically, maximum likelihood estimates are calculated for an ABAB:BABA study


Cross-over desigh; growth curve models; repeated measurements; maximum likelihood estimator

Published in

Laboratory Animals
2005, Volume: 136, number: 2, pages: 475-496

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    UKÄ Subject classification

    Animal and Dairy Science
    Fish and Aquacultural Science
    Forest Science
    Environmental Sciences related to Agriculture and Land-use
    Agricultural Science
    Landscape Architecture
    Food Science
    Economics and Business
    Social Sciences
    Renewable Bioenergy Research
    Veterinary Science

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