Metabolomics study of cereal grains reveals the discriminative metabolic markers associated with anatomical compartments

Abstract

This study used NMR-based metabolomics to compare the metabolic profile of different anatomical compartments of cereal grains i.e. bran and endosperm in order to gain further insights into their possible role in the beneficial health effects of whole grain products (WG). Polar water-soluble metabolites in 64 bran and endosperm, samples from rye and wheat were observed using 600 MHz NMR. Bran samples had higher contents of 12 metabolites than endosperm samples. A comparative approach revealed higher contents of azelaic acid and sebacic acid in bran than in endosperm. In a pilot study, the consumption of WG rye bread (485 g) caused NMR signals in 24h urine corresponding to azelaic acid. The relatively high abundance, anatomical specificity, pattern of metabolism, urinary excretion in human, antibacterial, and anticancer activities suggest further studying of azelaic acid when exposure to WG or beneficial effects of WG are investigated.

Keywords

Metabolomics; NMR; wholegrain; rye; wheat; metabolites; biomarkers

Published in

Italian Journal of Food Science
2015, volume: 27, number: 2, pages: 142-150
Publisher: CHIRIOTTI EDITORI

SLU Authors

• Moazzami, Ali

  • The Department of Chemistry and Biotechnology, Swedish University of Agricultural Sciences
    

Global goals (SDG)

SDG3 Good health and well-being

UKÄ Subject classification

Food Science

Permanent link to this page (URI)

https://res.slu.se/id/publ/73442