Research article - Peer-reviewed, 2015
Metabolomics study of cereal grains reveals the discriminative metabolic markers associated with anatomical compartments
Coulomb, Marie; Gombert, Antonin; Moazzami, AliAbstract
This study used NMR-based metabolomics to compare the metabolic profile of different anatomical compartments of cereal grains i.e. bran and endosperm in order to gain further insights into their possible role in the beneficial health effects of whole grain products (WG). Polar water-soluble metabolites in 64 bran and endosperm, samples from rye and wheat were observed using 600 MHz NMR. Bran samples had higher contents of 12 metabolites than endosperm samples. A comparative approach revealed higher contents of azelaic acid and sebacic acid in bran than in endosperm. In a pilot study, the consumption of WG rye bread (485 g) caused NMR signals in 24h urine corresponding to azelaic acid. The relatively high abundance, anatomical specificity, pattern of metabolism, urinary excretion in human, antibacterial, and anticancer activities suggest further studying of azelaic acid when exposure to WG or beneficial effects of WG are investigated.Keywords
Metabolomics; NMR; wholegrain; rye; wheat; metabolites; biomarkersPublished in
Italian Journal of Food Science2015, volume: 27, number: 2, pages: 142-150
Publisher: CHIRIOTTI EDITORI
Authors' information
Coulomb, Marie
Gombert, Antonin
Swedish University of Agricultural Sciences, The Department of Chemistry and Biotechnology
Sustainable Development Goals
SDG3 Good health and wellbeing
UKÄ Subject classification
Food Science
URI (permanent link to this page)
https://res.slu.se/id/publ/73442