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Research article - Peer-reviewed, 2016

Iron chelators target both proliferating and quiescent cancer cells

Fryknas, Marten; Zhang, Xiaonan; Bremberg, Ulf; Senkowski, Wojciech; Olofsson, Maria Hagg; Brandt, Peter; Persson, Ingmar; D'Arcy, Padraig; Gullbo, Joachim; Nygren, Peter; Schughart, Leoni Kunz; Linder, Stig; Larsson, Rolf

Abstract

Poorly vascularized areas of solid tumors contain quiescent cell populations that are resistant to cell cycle-active cancer drugs. The compound VLX600 was recently identified to target quiescent tumor cells and to inhibit mitochondrial respiration. We here performed gene expression analysis in order to characterize the cellular response to VLX600. The compound-specific signature of VLX600 revealed a striking similarity to signatures generated by compounds known to chelate iron. Validation experiments including addition of ferrous and ferric iron in excess, EXAFS measurements, and structure activity relationship analyses showed that VLX600 chelates iron and supported the hypothesis that the biological effects of this compound is due to iron chelation. Compounds that chelate iron possess anti-cancer activity, an effect largely attributed to inhibition of ribonucleotide reductase in proliferating cells. Here we show that iron chelators decrease mitochondrial energy production, an effect poorly tolerated by metabolically stressed tumor cells. These pleiotropic features make iron chelators an attractive option for the treatment of solid tumors containing heterogeneous populations of proliferating and quiescent cells.

Keywords

Iron(II) chelate, cancer, therapy, proliferating cells, quiescent cells

Published in

Scientific Reports
2016, volume: 6, article number: 38343

Authors' information

Fryknäs, Mårten
Uppsala University
Swedish University of Agricultural Sciences, The Department of Chemistry and Biotechnology
Larsson, Rolf
Uppsala University

Sustainable Development Goals

SDG3 Good health and wellbeing

UKÄ Subject classification

Medicinal Chemistry
Biomaterials Science

Publication Identifiers

DOI: https://doi.org/10.1038/srep38343

URI (permanent link to this page)

https://res.slu.se/id/publ/78343