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Research article - Peer-reviewed, 2016

Carprofen neither reduces postoperative facial expression scores in rabbits treated with buprenorphine nor alters long term bone formation after maxillary sinus grafting

Hedenqvist, Patricia; Trbakovic, Amela; Thor, Andreas; Ley, Cecilia; Ekman, Stina; Jensen Waern, Marianne


In connection with bilateralmaxillary sinus augmentation, the acute effects of the nonsteroidal anti-inflammatory drug carprofen on facial expressions and long-termeffects on bone formation were evaluated in 18male New ZealandWhite rabbits. A 10 × 10mmbonewindowwas drilled in themaxilla, the sinusmembrane elevated and a titanium mini-implant inserted. One of two test materialswas randomly inserted unilaterally and bovine bone chips (control) on the contralateral side in the created space. Rabbits were randomly allocated to receive buprenorphine plus carprofen (n = 9) or buprenorphine plus saline (n = 9) postoperatively. Buprenorphine was administered subcutaneously every 6 h for 3 days in a tapered dose (0.05-0.01 mg/kg) and carprofen (5 mg/kg) or saline administered subcutaneously 1 h before, and daily for 4 days postoperatively. To assess pain, clinical examination, body weight recording and scoring of facial expressions from photos taken before, and 6-13 h after surgery were performed. Twelve weeks after surgery the rabbits were euthanized and sections of maxillary bones and sinuses were analysed with histomorphometry and by qualitative histology. Carprofen had no effect onmean facial expression scores,which increased from0.0 to 3.6 (carprofen) and 4.3 (saline), of a maximum of 8.0. Neither did carprofen have an effect on bone formation or implant incorporation, whereas the test materials had. In conclusion, treatment with 5mg/kg carprofen once daily for 5 days did not reduce facial expression scores after maxillary sinus augmentation in buprenorphine treated rabbits and did not affect long term bone formation.


Bone formation; Pain; NSAID; Implant; Sinus-lift; Experimental animal

Published in

Research in Veterinary Science
2016, volume: 107, pages: 123-131
Publisher: Elsevier

Authors' information

Swedish University of Agricultural Sciences, Department of Clinical Sciences
Trbakovic, Amela
Uppsala University
Thor, Andreas
Uppsala University
Swedish University of Agricultural Sciences, Department of Clinical Sciences

UKÄ Subject classification

Other Medical Sciences not elsewhere specified
Other Veterinary Science

Publication Identifiers


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