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Research article - Peer-reviewed, 2003

Tetrameric NAD-dependent alcohol dehydrogenase

Karlsson A, El-Ahmad M, Johansson K, Shafqat J, Jornvall H, Eklund H, Ramaswamy S

Abstract

Three-dimensional structures of the ethanol-induced, tetrameric alcohol dehydrogenase from Escherichia coli have recently been determined in the absence and presence of NAD. The structure of the E coli enzyme is similar to those of the dimeric mammalian alcohol dehydrogenases, but it has a deletion of 21 residues located at the surface of the catalytic domain. The catalytic zinc ions have two different types of coordination, which are also observed in the class III dimeric mammalian alcohol dehydrogenase. Comparison of the structures provide new insights into the relationship between tetrameric and dimeric alcohol dehydrogenases and provide a link to the structure of the tetrameric yeast alcohol dehydrogenase. circle dot 2002 Elsevier Science Ireland Ltd. All rights reserved

Published in

Chemico-Biological Interactions
2003, Volume: 143, pages: 239-245
Publisher: ELSEVIER SCI IRELAND LTD

      SLU Authors

    • Karlsson Tiselius, Andreas

      • Department of Molecular Biology, Swedish University of Agricultural Sciences

      • Eklund, Hans

        • Department of Molecular Biology, Swedish University of Agricultural Sciences

      UKÄ Subject classification

      Renewable Bioenergy Research
      Food Science

      Publication Identifiers

      DOI: https://doi.org/10.1016/S0009-2797(02)00222-3

      Permanent link to this page (URI)

      https://res.slu.se/id/publ/800