Abstract

Objective The objective of the present study was to examine the relationship between plasma alkyresorcinol (AR) concentrations, which are biomarkers of whole-grain intake, and atherosclerotic progression over 3 years in postmenopausal women with coronary artery disease.Design Plasma AR concentrations were measured by a validated GC-MS method in fasting plasma samples. Atherosclerosis progression was assessed using change in mean minimal coronary artery diameter (MCAD) and percentage diameter stenosis (%ST), based on mean proximal vessel diameter across up to ten coronary segments. Dietary intake was estimated using a 126-item interviewer-administered FFQ.Setting A prospective study of postmenopausal women participating in the Estrogen Replacement and Atherosclerosis trial.Subjects For the analysis of plasma AR concentrations and atherosclerotic progression, plasma samples and follow-up data on angiography were available for 182 women.Results Mean whole-grain intake was 96 (se 06) servings per week. After multivariate adjustment, no significant associations were observed between plasma AR concentrations and change in mean MCAD or progression of %ST. Plasma AR concentrations were significantly correlated with dietary whole grains (r=035, P<0001), cereal fibre (r=033, P<0001), bran (r=015, P=005), total fibre (r=022, P=0003) and legume fibre (r=015, P=004), but not refined grains, fruit fibre or vegetable fibre.Conclusions Plasma AR concentrations were not significantly associated with coronary artery progression over a 3-year period in postmenopausal women with coronary artery disease. A moderate association was observed between plasma AR concentrations and dietary whole grains and cereal fibre, suggesting it may be a useful biomarker in observational studies.

Keywords

Alkylresorcinols; Whole grains; Biomarkers; Coronary artery disease

Published in

Public Health Nutrition
2016, Volume: 19, number: 2, pages: 326-331
Publisher: CAMBRIDGE UNIV PRESS

SLU Authors

• Landberg, Rikard

  • Department of Molecular Sciences, Swedish University of Agricultural Sciences
    
  • Karolinska Institute

Sustainable Development Goals

SDG3 Ensure healthy lives and promote well-being for all at all ages


UKÄ Subject classification

Nutrition and Dietetics
Food Science
Public Health, Global Health, Social Medicine and Epidemiology


Publication identifier

DOI: https://doi.org/10.1017/S1368980015001123

Permanent link to this page (URI)

https://res.slu.se/id/publ/80521